Related Experiment Video
Updated: May 30, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
[Developmental status of new antituberculous drugs]
Masayuki Igarashi1, Yoshiaki Takahashi
1Institute of Microbial Chemistry.
Abstract:
Worldwide, there are nearly 9 million new cases of active tuberculosis (TB) and 1.8 million associated deaths every year. Especially, difficulty of the chemotherapy in TB/HIV co-infection and also prevalence of multi drug-resistant tuberculosis (MDR-TB) as well as extensively drug-resistant tuberculosis (XDR-TB) make serious clinical problems. Development of the new drugs is essential to overcome of such clinical difficulty as described above. The developmental status of the new drugs has at present advanced greatly by the leading contribution of the international organization such as Global Alliance for TB Drug Development and Stop TB Partnership in this decade. This article reviews the developing new compounds at presents as the key drugs for treatment of TB now.
Related Concept Videos
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis
