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Kappa L-chain primary nodular lung amyloidosis: a case report

B Moscatelli1, G B Capoccetta, P Anselmi

  • 1Department of Internal Medicine, Fatebenefratelli Hospital – AFaR Isola Tiberina, Rome, Italy.

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
|August 16, 2011
PubMed
Summary

No abstract available in PubMed .

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...