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Ulcerative cystitis associated with phenylbutazone administration in two horses
Monica Aleman1, Jorge E Nieto, Jamie K Higgins
1William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA. mraleman@ucdavis.edu
Journal of the American Veterinary Medical Association
|August 16, 2011
Summary
Phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID), may cause ulcerative cystitis and hematuria in horses. Discontinuing phenylbutazone and administering prostaglandins resolved these adverse effects.
Area of Science:
- Veterinary Medicine
- Equine Health
- Pharmacology
Background:
- Phenylbutazone is a commonly used NSAID in horses for pain and inflammation management.
- Prolonged administration of NSAIDs can lead to gastrointestinal and urinary tract adverse effects.
Observation:
- Two horses presented with hematuria after prolonged phenylbutazone treatment.
- Cystoscopy revealed urinary bladder ulceration and hemorrhage in both horses.
- Gastric ulceration was also noted in both cases.
Findings:
- Clinicopathologic findings included anemia, hypoalbuminemia, and elevated BUN.
- Urinalysis showed proteinuria and red blood cells, with no signs of infection.
- Discontinuation of phenylbutazone and administration of misoprostol led to resolution of hematuria and cystoscopic findings.
Implications:
- Phenylbutazone administration is suspected to cause ulcerative cystitis in horses.
- Early detection and discontinuation of NSAID treatment are crucial for managing adverse effects.
- Further research is needed to confirm the direct link between phenylbutazone and ulcerative cystitis.
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