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Related Experiment Video

Updated: May 30, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Published on: September 13, 2022

Recent developments in protein and cell-targeted aptamer selection and applications.

Jun Liu1, Mingxu You, Ying Pu

  • 1Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Current Medicinal Chemistry
|August 16, 2011
PubMed
Summary

Aptamers, or oligonucleotide sequences, are versatile tools for biomarker discovery and drug delivery due to their specific binding capabilities. This review discusses optimizing the Systematic Evolution of Ligands by EXponential enrichment (SELEX) process for efficient aptamer development and application.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Aptamers are oligonucleotide molecules with unique three-dimensional structures enabling specific target binding.
  • Their easily modifiable chemical structures make them suitable for diverse biomedical applications.
  • Systematic Evolution of Ligands by EXponential enrichment (SELEX) is a key method for aptamer generation.

Purpose of the Study:

  • To review the fundamental principles and recent advancements in SELEX process design.
  • To provide guidelines for enhancing the efficiency of aptamer isolation.
  • To explore the biomedical and bioanalytical applications of modified aptamer structures.

Main Methods:

  • Discussion of SELEX (Systematic Evolution of Ligands by EXponential enrichment) principles and modifications.
  • Review of biochemical strategies for aptamer structure modification.
  • Analysis of literature on aptamer applications in diagnostics and therapeutics.

Main Results:

  • SELEX process optimization can lead to more efficient aptamer isolation.
  • Biochemical modifications enhance aptamer utility in various applications.
  • Aptamers demonstrate high affinity and specificity for diverse targets, including proteins and cancer cells.

Conclusions:

  • Optimized SELEX protocols are crucial for efficient aptamer generation.
  • Modified aptamers offer significant potential in biomarker discovery, diagnostics, imaging, and drug delivery.
  • Aptamers represent a powerful class of molecules for advancing biomedical and bioanalytical sciences.