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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Aptamers against cell surface receptors: selection, modification and application.

J Wang1, G Li

  • 1Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 210093 Nanjing, China.

Current Medicinal Chemistry
|August 16, 2011
PubMed
Summary
This summary is machine-generated.

Aptamers, or synthetic oligonucleotides, offer advantages over antibodies for targeting cell-surface receptors. These molecules show promise as therapeutic and diagnostic agents, particularly in oncology.

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Last Updated: May 30, 2026

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Discovery

Background:

  • Aptamers are synthetic oligonucleotides with high affinity and specificity for various targets.
  • They offer advantages over antibodies, including smaller size, easier synthesis, and lower immunogenicity.
  • Aptamers can inhibit target molecules, suggesting therapeutic potential.

Purpose of the Study:

  • To review the identification, modification, and working mechanisms of aptamers targeting cell-surface receptors.
  • To discuss the challenges and potential of aptamers in clinical applications.

Main Methods:

  • Selection strategies for aptamers against cell-surface receptors.
  • In vitro and in vivo experimental validation of aptamer binding and efficacy.

Main Results:

  • Aptamers demonstrate distinct binding affinities to recombinant targets and cell-surface receptors.
  • In vivo studies show aptamers can inhibit tumor growth mediated by overexpressed receptors.
  • Aptamers show potential as anti-tumor therapeutic drugs.

Conclusions:

  • Identifying aptamers against cell-surface receptors is challenging but feasible.
  • Aptamers targeting cell-surface receptors hold significant therapeutic and diagnostic potential.
  • Future research may expand the clinical utility of aptamers in oncology and beyond.