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Updated: May 30, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Regulatory T cells in transplantation
1Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. kathryn.wood@nds.ox.ac.uk
Regulatory T cells (Treg) are crucial for immune tolerance and can prevent organ transplant rejection. Preclinical studies show Treg cell therapy is safe and feasible, indicating therapeutic potential for transplantation.
Area of Science:
- Immunology
- Transplantation immunology
- Cellular therapy
Background:
- T Regulatory cells (Treg) are essential for maintaining immunological tolerance to self and foreign antigens.
- Treg cells have demonstrated the ability to suppress immune responses against transplanted organs.
Purpose of the Study:
- To review the role of Treg cells in controlling allograft rejection.
- To assess the therapeutic potential of Treg cell therapy in transplantation.
Main Methods:
- Review of experimental transplant models.
- Analysis of preclinical Treg cell therapy studies.
Main Results:
- Treg cells effectively control both acute and delayed allograft rejection in experimental models.
- Preclinical Treg cell therapy trials have shown promising safety and feasibility.
Conclusions:
- Treg cells represent a promising cellular therapy for preventing transplant rejection.
- Further clinical investigation into Treg cell therapy for transplantation is warranted.
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