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Updated: May 30, 2026
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Malignancy development in lung transplant patients
M T Parada1, C Sepúlveda, A Alba
1Transplant Center, Clinica Las Condes, Santiago, Chile.
Introduction:
The most common neoplasias among transplant patients are skin cancers and lymphoproliferative disorders.
Objective:
To characterize lung transplanted recipients who developed malignancies.
Methods:
A retrospective analysis of clinical records of our patients.
Results:
Seven patients developed malignancies: skin cancer (n = 5; 71%), and adenocarcinomas of prostatic, gastric, and lung (n = 1 each). One patient developed two hematologic malignancies: T-cell lymphoma and multiple myeloma. Among five patients who died (71%), 3 were due to advanced neoplasia. The mean presentation time was 4.3 years. Skin cancers were resected. The patient with lung adenocarcinoma developed pleural involvement and died. The patient with T-cell lymphoma was treated, but succumbed afterward due to multiple myeloma. The patient with gastric adenocarcinoma died at 3 months after the diagnosis, and the patient with prostate cancer underwent surgery without disease recurrence.
Conclusion:
Malignancies are a late complication of transplant recipients that require a prompt diagnosis and treatment to improve outcomes.
