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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: May 30, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Malignancy development in lung transplant patients.

M T Parada1, C Sepúlveda, A Alba

  • 1Transplant Center, Clinica Las Condes, Santiago, Chile.

Transplantation Proceedings
|August 16, 2011
PubMed
Summary
This summary is machine-generated.

Malignancies are a late complication in transplant recipients, with skin cancers being most common. Prompt diagnosis and treatment are crucial for improving outcomes in these patients.

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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

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Related Experiment Videos

Last Updated: May 30, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

Area of Science:

  • Oncology
  • Transplantation Medicine
  • Immunology

Background:

  • Solid organ and hematopoietic stem cell transplant recipients face an increased risk of secondary malignancies.
  • Common post-transplant cancers include skin cancers and lymphoproliferative disorders.

Purpose of the Study:

  • To characterize the incidence and types of malignancies in lung transplant recipients.
  • To analyze the clinical course and outcomes of transplant patients who develop cancer.

Main Methods:

  • Retrospective analysis of clinical records.
  • Review of patient demographics, cancer diagnoses, treatment, and outcomes.

Main Results:

  • Seven lung transplant recipients developed malignancies, with skin cancer (71%) being the most frequent.
  • Other malignancies included lung, gastric, and prostate adenocarcinomas, T-cell lymphoma, and multiple myeloma.
  • Mortality was high (71%), with 3 deaths attributed to advanced neoplasia; mean presentation time was 4.3 years post-transplant.

Conclusions:

  • Malignancies represent a significant late complication following transplantation.
  • Timely diagnosis and effective treatment strategies are essential for improving survival rates in transplant recipients with cancer.