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Updated: May 30, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
Published on: January 18, 2019
Infection-related glomerulonephritis: understanding mechanisms
1Ohio State University Medical Center, Columbus, OH, USA. tibor.nadasdy@osumc.edu
Abstract:
The epidemiology of infection-related glomerulonephritis is undergoing striking changes, particularly in developed countries. The incidence of acute poststreptococcal glomerulonephritis (PSAGN) is decreasing because of the successful treatment of streptococcal infections. In contrast, because of the emergence of antibiotic-resistant staphylococcus strains, such as methicillin-resistant Staphylococcus aureus (MRSA), the incidence of Staphylococcus aureus infection-associated glomerulonephritis (SAAGN) is on the rise. In this review, we focus on the pathogenesis of PSAGN and SAAGN, but also emphasize the clinical importance of differentiating between two major forms of infection-related glomerulonephritis: postinfectious glomerulonephritis (such as PSAGN) and glomerulonephritis associated with active infection (such as SAAGN).
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The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...