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Updated: May 30, 2026
Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Randomized controlled trial of restrictive fluid management in transient tachypnea of the newborn
Annemarie Stroustrup1, Leonardo Trasande, Ian R Holzman
1Mount Sinai Medical Center, New York, NY, USA. Annemarie.Stroustrup@mssm.edu
Objective:
To determine the effect of mild fluid restriction on the hospital course of neonates with transient tachypnea of the newborn (TTN).
Study Design:
In this pilot prospective randomized controlled trial of 64 late preterm and term neonates diagnosed with TTN at a single tertiary care hospital in the United States, patients were randomized to receive standard fluid management or mild fluid restriction. The primary outcome was duration of respiratory support. Secondary outcomes were duration of admission to the intensive care unit, time to first enteral feed, and total and composite hospital costs. Results were analyzed by t-test, χ(2) test, Kaplan-Meier estimation, and proportional hazards regression.
Results:
Fluid restriction did not cause adverse events or unsafe dehydration. Fluid management strategy did not affect primary or secondary outcomes in the total study population. Fluid restriction significantly reduced the duration of respiratory support (P = .008) and hospitalization costs (P = .017) in neonates with severe TTN.
Conclusion:
Mild fluid restriction appears to be safe in late preterm and term neonates with uncomplicated TTN. Fluid restriction may be of benefit in decreasing the duration of respiratory support and reducing hospitalization costs in term and late preterm neonates with uncomplicated severe TTN.
