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Updated: May 30, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
Published on: March 1, 2011
Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines
Brianne R Barker1, Debra J Taxman, Jenny P-Y Ting
1Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.
Abstract:
The inflammasome-forming NLRs are well characterized members of a protein complex mediating the activation of caspase-1 and the cleavage of pro-IL-1β and pro-IL-18 into their active, secreted forms. New data suggest that components of the inflammasome cascade may have roles in influencing inflammasome-independent pathways of cytokine production. These influences on other immune cytokine pathways are complemented by data suggesting that non-inflammasome cytokines can influence the activation of the inflammasome, either directly or by influencing transcription of inflammasome components. The crosstalk between these cytokine cascades may lead to increased abilities for the cell to respond to diverse pathogen threats.
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