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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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Updated: May 30, 2026

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

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Published on: May 26, 2017

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

Annika Armulik1, Guillem Genové, Christer Betsholtz

  • 1Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Developmental Cell
|August 16, 2011
PubMed
Summary
This summary is machine-generated.

Pericytes regulate blood vessel development and function, impacting diseases like diabetic retinopathy and cancer. Ongoing research clarifies their identity, origins, and potential as therapeutic targets.

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Area of Science:

  • Vascular Biology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Pericytes are mural cells crucial for microvessel integrity and function.
  • They play roles in development, homeostasis, and diseases such as diabetic retinopathy, fibrosis, and cancer.

Purpose of the Study:

  • To review the historical and current understanding of pericyte biology.
  • To highlight emerging concepts and challenges in pericyte research.
  • To discuss the potential of pericytes as therapeutic targets.

Main Methods:

  • Literature review and synthesis of existing research on pericytes.
  • Analysis of studies investigating pericyte identity, ontogeny, and differentiation potential.
  • Examination of pericytes' roles in various physiological and pathological contexts.

Main Results:

  • Pericytes are implicated in vascular morphogenesis and homeostasis.
  • Evidence suggests some pericytes possess mesenchymal stem cell properties.
  • Confusion persists regarding pericyte identity, origin, and differentiation capacity.

Conclusions:

  • Pericytes are key regulators of microvascular function with broad implications in disease.
  • Further research is needed to resolve ambiguities surrounding pericyte identity and lineage.
  • Pericytes represent promising targets for therapeutic interventions in various conditions.