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Liver enzyme adaptation after lithium administration in handled and nonhandled rats
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|September 1, 1977
Summary
Infant handling and lithium affect liver enzymes and stress hormones. Handled animals show altered corticosterone and glucose levels, indicating lithium modifies stress response systems.
Area of Science:
- Endocrinology
- Neuroscience
- Animal Behavior
Background:
- Infant handling is known to alter stress responses and hormonal regulation.
- Lithium administration can impact various physiological systems, including hormonal feedback loops.
Purpose of the Study:
- To investigate the combined effects of infant handling and lithium administration on liver enzymes and hormonal regulation.
- To determine how these factors influence corticosterone levels and glucose metabolism.
Main Methods:
- Examined the interaction of lithium and infant handling on hormonally regulated liver enzymes.
- Measured morning corticosterone levels and serum glucose during refeeding after fasting in handled and non-handled animals.
Main Results:
- Handled animals exhibited increased morning corticosterone with lithium feeding.
- Elevated serum glucose was observed in handled animals during refeeding post-fasting.
- Lithium altered serum corticosterone in response to fasting stress and diurnal cycles.
Conclusions:
- Infant handling and lithium administration differentially affect hormonal regulation and stress responses.
- Results suggest lithium further modifies the ACTH secretion feedback system, particularly in handled animals.