Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pruritus. Current concepts in pathogenesis and treatment.

G Lorette1, L Vaillant

  • 1Service de Dermatologie, CHU Trousseau, Tours, France.

Drugs
|February 1, 1990
PubMed
Summary

Pruritus, or itch, is a common symptom with poorly understood mechanisms. Current treatments like antihistamines offer incomplete relief, highlighting the need for better understanding and management of itch.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Hormonal receptors in cutaneous vascular malformations: 51 cases.

Virchows Archiv : an international journal of pathology·2019
Same author

Hormonal receptors in cutaneous vascular malformations: 51 cases.

Virchows Archiv : an international journal of pathology·2019
Same author

[The Annales de dermatologie: 1997-2003].

Annales de dermatologie et de venereologie·2019
Same author

Clinical and haemodynamic risk factors associated with discrepancies in lower limb length with capillary malformations: data from the national paediatric French cohort CONAPE.

The British journal of dermatology·2017
Same author

[Superficial cystic lymphatic malformations].

Annales de dermatologie et de venereologie·2017
Same author

Nail features in healthy term newborns: a single-centre observational study of 52 cases.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016

Area of Science:

  • Neurology
  • Dermatology
  • Pathophysiology

Background:

  • Pruritus is a complex sensation causing an urge to scratch.
  • Histamine is a key stimulus inducing pruritus.
  • Neural pathways involve unmyelinated C fibres and the spinothalamic tract.

Purpose of the Study:

  • To review the current understanding of pruritus mechanisms.
  • To discuss challenges in evaluating pruritus treatments.
  • To highlight the limitations of existing therapies.

Main Methods:

  • Literature review of pruritus pathophysiology.
  • Analysis of current treatment strategies and their efficacy.
  • Discussion of diagnostic and therapeutic challenges.

Main Results:

  • The exact mechanisms of pruritus remain largely unknown.
  • Evaluating pruritus is difficult, often focusing on scratching rather than the sensation itself.
  • Antihistamines are first-line treatments but provide incomplete relief.

Conclusions:

  • Effective treatment of pruritus requires addressing the underlying cause whenever possible.
  • Further research into pruritus mechanisms is crucial for developing effective therapies.
  • Current treatments have limitations, necessitating improved therapeutic approaches.

Related Experiment Videos