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Updated: May 30, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
New insights into asthma pathogenesis and treatment
Stanley J Szefler1, Azzeddine Dakhama
1Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics, Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA. szeflers@njhealth.org
Current Opinion in Immunology
|August 16, 2011
Summary
Current asthma care is symptom-based. Future strategies require personalized medicine, understanding disease natural history, and reducing health disparities for better asthma control and fewer exacerbations.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Personalized Medicine
Background:
- Current asthma management primarily relies on symptom-based approaches.
- National guidelines exist but do not fully address individual patient needs or disease progression.
- Significant challenges remain in preventing asthma exacerbations and reducing health disparities.
Purpose of the Study:
- To review the benefits and limitations of current asthma management strategies.
- To explore new research impacting future asthma care directions.
- To discuss insights into asthma mechanisms for improved control.
Main Methods:
- Literature review of recent reports and studies on asthma management.
- Analysis of current asthma guidelines and their effectiveness.
- Exploration of emerging concepts like personalized medicine and systems biology.
Main Results:
- Current symptom-based management has limitations in altering disease natural history.
- New approaches focusing on individualization, exacerbation prevention, and health equity are needed.
- Personalized medicine and systems biology offer potential for improved asthma control.
Conclusions:
- Improved asthma management requires a shift beyond symptom control.
- Understanding asthma's natural history and individualizing care are crucial.
- Integrating personalized medicine and addressing health disparities may alleviate the asthma burden.
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