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Published on: March 17, 2020
Stable long-term pulmonary function after myeloablative double cord blood transplant
Filippo Milano1, Jason W Chien, Ivy Riffkin
1Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA. fmilano@fhcrc.org
Summary
This study found that double cord blood transplantation after myeloablative conditioning has a low risk of pulmonary dysfunction. Lung function remained stable one year post-transplant for most patients.
Area of Science:
- Hematology
- Pulmonology
- Transplantation Medicine
Background:
- Pulmonary dysfunction is a known complication following myeloablative allogeneic stem cell transplantation.
- The pulmonary risk associated with alternative donor sources, specifically cord blood, remains under-investigated.
Purpose of the Study:
- To investigate the incidence and severity of pulmonary dysfunction after myeloablative conditioning followed by double cord blood transplantation.
- To assess changes in pulmonary function tests (PFTs) at various time points post-transplantation.
Main Methods:
- Retrospective analysis of 56 patients undergoing myeloablative conditioning and double cord blood transplantation.
- Pulmonary function tests were conducted pre-transplantation and at 80 days, 1 year, and 2 years post-transplantation.
Main Results:
- No significant mean change in PFT values was observed at 1 year post-transplantation compared to baseline.
- Lung function decline from baseline to 1 year was less than 5% in 75% of patients.
- The cumulative incidence of noninfectious pulmonary complications was 9.7%.
Conclusions:
- Double cord blood transplantation following myeloablative conditioning appears to carry a low risk of significant pulmonary dysfunction.
- Lung function is generally preserved one year after this transplantation strategy.
- Further prospective studies are warranted to validate these findings.
