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Cortico-striatal disconnection within the cingulo-opercular network in schizophrenia revealed by intrinsic functional
Pei-Chi Tu1, Jen-Chuen Hsieh, Cheng-Ta Li
1Department of Medical Research and Education, Taipei Veterans General Hospital, Institute of Neuroscience, School of Life Science, National Yang-Ming University, Taipei 112, Taiwan.
Neuroimage
|August 16, 2011
Summary
Schizophrenia is linked to functional disconnection within the cingulo-opercular network (CON). This study found reduced connectivity in the putamen, correlating with negative symptoms and impacting working memory in patients.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- The cingulo-opercular network (CON) is crucial for cognitive functions often impaired in schizophrenia.
- Previous research suggests functional abnormalities within the CON in schizophrenia patients.
Purpose of the Study:
- To investigate functional connectivity within the CON in individuals with schizophrenia using functional connectivity magnetic resonance imaging (fcMRI).
- To test the hypothesis that schizophrenia is associated with functional disconnection within the CON.
Main Methods:
- Utilized resting-state fcMRI in 30 schizophrenia patients and 30 healthy controls.
- Derived the CON using a dorsal anterior cingulate (dACC) seed and analyzed functional connectivity.
- Performed between-group comparisons and network analyses with multiple regions of interest (ROIs).
Main Results:
- Schizophrenia patients exhibited significantly reduced functional connectivity in the bilateral putamens compared to controls.
- Network analysis revealed widespread cortico-striatal disconnection within the CON in schizophrenia.
- These disconnections correlated with the severity of negative symptoms.
Conclusions:
- Schizophrenia is characterized by significant cortico-striatal disconnection within the CON.
- Findings support the cortico-striatal disconnection hypothesis of schizophrenia.
- Disrupted CON connectivity may underlie cognitive deficits in schizophrenia.
