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Updated: May 30, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Acute ischemia manifestation in a patient with coronary slow flow phenomenon
1Department of Cardiology, American Hospital, Tirana, Albania. bhorjeti@spitaliamerikan.com
Insights
Coronary slow flow phenomenon, a cause of chest pain and ischemia, improved with heparin. This condition warrants consideration in acute coronary syndrome diagnoses.
Area of Science:
- Cardiology
- Vascular Medicine
Background:
- Acute coronary syndromes (ACS) are typically associated with significant coronary artery stenosis.
- Chest pain with normal coronary arteries presents a diagnostic challenge.
Observation:
- A patient presented with anginal chest pain and ischemic electrocardiographic changes.
- Coronary angiography revealed slow flow in all three coronary arteries without significant stenosis or ectasia.
Findings:
- Intravenous unfractionated heparin infusion for 24 hours led to improved coronary flow.
- Electrocardiographic changes indicative of ischemia showed significant improvement post-heparin treatment.
Implications:
- Coronary slow flow phenomenon (CSFP) should be recognized as a distinct entity in the differential diagnosis of ACS.
- Further clinical research is necessary to elucidate the pathophysiology and optimal management of chest pain associated with normal coronary arteries.
Abstract:
A patient with anginal chest pain and electrocardiographic changes suggesting ischemia was referred to our hospital. Coronary angiography revealed no significant stenosis or ectasia but only slow flow in all 3 coronary arteries. After infusion of unfractionated heparin for 24 hours, negative T waves became less deep, and repeated coronary angiography showed significant improvement of the coronary flow. The coronary slow flow phenomenon, together with the associated ischemic electrocardiographic changes, should be considered as a separate entity in the differential diagnosis of acute coronary syndromes. Additional clinical research is required to better understand the syndromes of chest pain with normal coronary arteries.
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