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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Electrochemical Gradient and Channel Proteins: An Overview01:21

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell.  This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Related Experiment Video

Updated: May 30, 2026

Novel Assay for Cold Nociception in Drosophila Larvae
06:52

Novel Assay for Cold Nociception in Drosophila Larvae

Published on: April 3, 2017

A cool channel in cold transduction.

Ramón Latorre1, Sebastián Brauchi, Rodolfo Madrid

  • 1Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Physiology (Bethesda, Md.)
|August 16, 2011
PubMed
Summary

Transient receptor potential melastatin 8 (TRPM8) channels detect cold temperatures. This review covers TRPM8

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Physiology

Background:

  • Transient receptor potential melastatin 8 (TRPM8) is a key ion channel involved in thermosensation.
  • TRPM8 mediates the detection of cold stimuli in the somatosensory system.
  • It is activated by cold, cooling compounds, and voltage.

Purpose of the Study:

  • To review the biophysical properties of TRPM8.
  • To discuss the physiological role of TRPM8 in cold detection.
  • To explore the near-membrane trafficking mechanisms of TRPM8.

Main Methods:

  • Literature review of existing research on TRPM8.
  • Analysis of biophysical data related to TRPM8 function.
  • Examination of studies on TRPM8's physiological significance and localization.

More Related Videos

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

Published on: June 3, 2016

Controllable Ion Channel Expression through Inducible Transient Transfection
10:00

Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

Related Experiment Videos

Last Updated: May 30, 2026

Novel Assay for Cold Nociception in Drosophila Larvae
06:52

Novel Assay for Cold Nociception in Drosophila Larvae

Published on: April 3, 2017

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
11:08

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

Published on: June 3, 2016

Controllable Ion Channel Expression through Inducible Transient Transfection
10:00

Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

Main Results:

  • TRPM8 exhibits unique biophysical characteristics enabling cold sensation.
  • TRPM8 plays a crucial role in the somatosensory system's response to cold.
  • TRPM8 undergoes specific trafficking to the cell membrane for proper function.

Conclusions:

  • TRPM8 is the primary molecular sensor for cold in mammals.
  • Understanding TRPM8's properties and trafficking is vital for research into thermosensation.
  • This review consolidates current knowledge on this important polymodal ion channel.