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Related Experiment Video

Updated: May 30, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Hypocalcemia in the critically ill patient.

Andrea Kelly1, Michael A Levine

  • 1Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Journal of Intensive Care Medicine
|August 16, 2011
PubMed
Summary

Diagnosing hypocalcemia in critically ill patients is challenging due to factors affecting total calcium levels. Measuring ionized calcium is crucial for accurate assessment and effective treatment strategies in critical care settings.

Keywords:
critical illnesshypocalcemiasepsis

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Last Updated: May 30, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Area of Science:

  • Critical Care Medicine
  • Endocrinology
  • Biochemistry

Background:

  • Hypocalcemia is a frequent complication in critically ill patients.
  • Interpreting total plasma calcium is difficult due to hypoalbuminemia and acid-base disorders.
  • Ionized calcium measurement is essential for accurate hypocalcemia diagnosis in critical care.

Purpose of the Study:

  • To review calcium metabolism regulation.
  • To discuss etiologies of hypocalcemia in neonatal, pediatric, and adult critical care.
  • To present treatment approaches and consensus for hypocalcemia in critically ill patients.

Main Methods:

  • Literature review on calcium metabolism and hypocalcemia.
  • Analysis of factors affecting total calcium interpretation.
  • Synthesis of current treatment guidelines for critical care hypocalcemia.

Main Results:

  • Normal calcium metabolism involves parathyroid hormone and vitamin D.
  • Hypocalcemia etiologies include parathyroid hormone and vitamin D disorders.
  • Accurate diagnosis relies on ionized calcium measurement, especially with hypoalbuminemia.

Conclusions:

  • Accurate hypocalcemia diagnosis in critical illness requires consideration of factors affecting total calcium.
  • Understanding calcium metabolism and etiologies guides treatment.
  • Evidence-based treatment strategies are vital for managing hypocalcemia in critically ill populations.