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Prediction of coronary artery disease using pulse wave velocity and retinal artery lesions

De-Zhao Wang1, Qing Tang, Qi Hua

  • 1Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China. huaqi5371@medmail.com.cn

The Tohoku Journal of Experimental Medicine
|August 16, 2011
PubMed

Insights

Coronary artery disease (CAD) can be predicted using non-invasive tests. Combining brachial-ankle pulse wave velocity (baPWV) and retinal artery lesion staging offers a convenient method for early CAD detection in symptomatic patients.

Area of Science:

  • Cardiovascular Medicine
  • Ophthalmology
  • Diagnostic Imaging

Background:

  • Coronary artery disease (CAD) is a major global cause of mortality.
  • Early diagnosis and prevention are crucial for managing CAD.
  • Coronary angiography, the gold standard, is not universally accessible, necessitating simpler screening tools.

Purpose of the Study:

  • To evaluate the efficacy of combining brachial-ankle pulse wave velocity (baPWV) and retinal artery lesion staging for predicting CAD.
  • To assess the utility of these non-invasive markers in symptomatic patients, including those with atypical chest pain.

Main Methods:

  • A study involving 472 Chinese patients with suspected CAD.
  • Coronary angiography was performed for definitive diagnosis.
  • Eye fundus examinations and baPWV measurements were conducted concurrently.

Main Results:

  • Patients with CAD showed a higher frequency of baPWV ≥ 1,400 cm/s or retinal artery atherosclerosis ≥ Stage 2.
  • Both baPWV and retinal artery atherosclerosis were significantly correlated with CAD presence, irrespective of chest pain type.
  • The combination of baPWV and retinal artery staging independently predicted CAD (OR: 10.37, p < 0.001).

Conclusions:

  • Elevated baPWV or advanced retinal artery lesions are valuable markers for predicting CAD, even in atypical presentations.
  • The combined use of these non-invasive methods provides a practical approach for screening symptomatic Chinese patients for CAD.

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