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Cryptococcal cellulitis in congenital lymphedema.

N Krywonis1, V N Kaye, P J Lynch

  • 1Department of Dermatology, University of Minnesota Hospital and Clinics, Minneapolis.

International Journal of Dermatology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Cryptococcal cellulitis can occur in patients with weakened cell-mediated immunity, such as those with intestinal lymphangiectasia and lymphedema. Early antifungal treatment with amphotericin B and 5-fluorocytosine led to a successful recovery.

Area of Science:

  • Medical Mycology
  • Immunology
  • Dermatology

Background:

  • Intestinal lymphangiectasia and congenital lymphedema can compromise cell-mediated immunity.
  • Cryptococcal infections, though typically systemic, can manifest in the skin.

Observation:

  • A 27-year-old female patient presented with cryptococcal cellulitis.
  • The patient had a history of intestinal lymphangiectasia and congenital lymphedema, predisposing her to immune dysfunction.

Findings:

  • Prompt administration of amphotericin B and 5-fluorocytosine achieved an excellent clinical outcome.
  • This case highlights a rare cutaneous manifestation of Cryptococcus in an immunocompromised host.

Implications:

  • Increased prevalence of compromised cell-mediated immunity may lead to more cases of cryptococcal cellulitis.

Related Experiment Videos

  • Physicians should consider fungal etiologies, including Cryptococcus, in the differential diagnosis of severe or atypical cellulitis.
  • Early and appropriate antifungal therapy is crucial for favorable outcomes in cryptococcal skin infections.