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Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate
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PlasmaLyte.

Sandro Rizoli1

  • 1Department of Surgery & Critical Care Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. sandro.rizoli@sunnybrook.ca

The Journal of Trauma
|August 16, 2011
PubMed
Summary
This summary is machine-generated.

PlasmaLyte solutions closely mimic human plasma and help correct acidosis. However, they may cause fluid overload and contain magnesium, with no proven superiority in trauma management.

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Area of Science:

  • Medical Science
  • Intensive Care Medicine
  • Emergency Medicine

Background:

  • PlasmaLyte is a balanced crystalloid solution family with various formulations used globally.
  • It is designed to closely resemble human plasma in electrolyte content, osmolality, and pH.
  • These solutions contain buffer anions like acetate, gluconate, and lactate, which convert to bicarbonate, aiding acidosis correction.

Purpose of the Study:

  • To review the properties, advantages, and potential concerns of PlasmaLyte solutions.
  • To evaluate the current evidence regarding PlasmaLyte's use in clinical practice, particularly in trauma and hypovolemic shock.
  • To assess if PlasmaLyte offers superior benefits compared to other crystalloids in specific medical scenarios.

Main Methods:

  • Literature review of PlasmaLyte formulations and their physiological effects.
  • Analysis of clinical data and studies concerning the use of PlasmaLyte in fluid resuscitation and acidosis management.
  • Examination of safety profiles, including potential adverse effects and unique concerns associated with PlasmaLyte.

Main Results:

  • PlasmaLyte effectively corrects volume and electrolyte deficits and addresses acidosis.
  • Common crystalloid issues like fluid overload, edema, and increased intracranial pressure can occur.
  • A notable concern is the presence of magnesium in most formulations, potentially impacting cardiovascular function and organ perfusion.
  • Limited research exists on its application in trauma or hypovolemic shock.

Conclusions:

  • PlasmaLyte offers benefits in fluid and electrolyte correction and acidosis management.
  • Potential adverse effects, including those related to magnesium content, require consideration.
  • There is currently no evidence to support PlasmaLyte's superiority over other crystalloids for prehospital management of traumatic hypovolemia.