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Updated: May 30, 2026

Trace Fear Conditioning in Mice
Published on: March 20, 2014
The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
Quan Lin1, Wei Wei, Carlos M Coelho
1Intellectual Development and Disabilities Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Abstract:
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.
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