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Related Experiment Video

Updated: May 30, 2026

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

A PARYLENE-BASED MICROELECTRODE ARRAY IMPLANT FOR SPINAL CORD STIMULATION IN RATS.

Mandheerej S Nandra¹, Igor A Lavrov, V Reggie Edgerton

¹California Institute of Technology, Pasadena, California, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|August 16, 2011

Summary

Researchers developed a new spinal cord implant for rats with paralysis. Pulsed stimulation from this parylene-based microelectrode array enabled recovery of hindlimb stepping function, offering hope for spinal cord injury treatment.

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Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays

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Published on: February 9, 2022

Area of Science:

Biomedical Engineering
Neuroscience
Regenerative Medicine

Background:

Spinal cord injury (SCI) often results in paralysis, significantly impacting motor function.
Current treatments for SCI have limitations in restoring lost neurological function.
Epidural electrical stimulation shows promise for functional recovery after SCI.

Purpose of the Study:

To design and fabricate a novel epidural spinal cord implant using a parylene-based microelectrode array.
To evaluate the efficacy of pulsed stimulation delivered by the implant in restoring hindlimb function in a rat model of complete spinal cord transection.
To investigate the potential of advanced microelectrode arrays for understanding spinal cord function and locomotion recovery.

Main Methods:

Development of a flexible parylene-based microelectrode array for epidural implantation.
Surgical implantation of the device in rats with complete spinal cord transection.
Application of pulsed electrical stimulation through the microelectrode array for up to eight weeks.
Assessment of hindlimb stepping functionality and biological responses.

Main Results:

Successful implantation and function of the parylene-based microelectrode array.
Demonstrated recovery of hindlimb stepping functionality in paralyzed rats following pulsed stimulation.
The microelectrode array provided high freedom and specificity in stimulation site selection.

Conclusions:

Parylene-based microelectrode arrays are effective for epidural spinal cord stimulation.
Pulsed stimulation via this implant can restore locomotion in a severe spinal cord injury model.
This technology advances understanding of spinal cord function and offers a potential therapeutic strategy for SCI.