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A Patient-Derived Xenograft Model for Venous Malformation

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[Pulmonary arteriovenous malformations in Rendu-Osler-Weber disease. Case report].

J Caldeira¹, N Guerra, J Roque

¹Serviço de Cirurgia Cardiotorácica do Hospital de Santa Maria, Centro Hospitalar Lisboa Norte.

Revista Portuguesa De Cirurgia Cardio-Toracica E Vascular : Orgao Oficial Da Sociedade Portuguesa De Cirurgia Cardio-Toracica E Vascular

|August 16, 2011

Summary

A 59-year-old woman was diagnosed with arteriovenous pulmonary malformation (AVPM) and Rendu-Osler-Weber disease (ROWD). Surgical treatment for her pulmonary vascular malformation was successful and without complications.

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Area of Science:

Vascular Medicine
Genetics
Pulmonology

Background:

Rendu-Osler-Weber disease (ROWD) is a genetic disorder causing vascular malformations in multiple organs.
Arteriovenous pulmonary malformations (AVPM) are rare vascular anomalies in the lungs.

Observation:

A 59-year-old woman presented with an incidentally discovered AVPM.
Her clinical history led to a diagnosis of ROWD, explaining the pulmonary vascular anomaly.

Findings:

The patient's AVPM was successfully treated with surgery.
The surgical intervention for the pulmonary vascular malformation was uneventful.

Implications:

This case highlights the importance of considering ROWD in patients with AVPM.
Understanding the pathophysiology and management of AVPM in ROWD is crucial for patient care.