Related Experiment Video
Updated: May 30, 2026

09:16
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
The effect of d,l-methamphetamine on simulated driving performance
Beata Y Silber1, Rodney J Croft, Luke A Downey
1Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia.
Psychopharmacology
|August 16, 2011
Summary
This study found that d,l-methamphetamine does not significantly affect simulated driving performance in healthy adults. Further research is needed to understand the drug
Area of Science:
- Forensic Toxicology
- Neuroscience
- Psychopharmacology
Background:
- Methamphetamine is a commonly abused illicit drug.
- Its presence is noted in drivers involved in road accidents.
- The impact of methamphetamine on driving behavior requires further investigation.
Purpose of the Study:
- To investigate the effects of d,l-methamphetamine on simulated driving performance.
- To determine if methamphetamine impairs or enhances driving capabilities.
Main Methods:
- Twenty healthy recreational stimulant users participated in a double-blind, placebo-controlled study.
- Participants received either d,l-methamphetamine (0.42 mg/kg) or a placebo.
- Driving performance was assessed 2.5 hours after drug administration.
Main Results:
- Blood and saliva concentrations of d,l-methamphetamine were measured.
- Observed methamphetamine levels did not significantly alter driving performance.
- No significant impairment or improvement in driving was detected.
Conclusions:
- d,l-methamphetamine administration showed no significant effect on simulated driving performance.
- These findings suggest that at the tested dosage and time point, methamphetamine does not impact driving ability.

