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Updated: May 30, 2026
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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 codon 72 polymorphism and recurrent pregnancy loss: a meta-analysis.
Wenru Tang1, Xuhong Zhou, Ying Chan
1Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, Kunming, Yunnan, 650224, China.
Journal of Assisted Reproduction and Genetics
|August 16, 2011
Summary
The p53 codon 72 Pro/Pro genotype is linked to a higher risk of recurrent pregnancy loss. This meta-analysis suggests a significant association, but further global studies are needed for confirmation.
Area of Science:
- Genetics
- Reproductive Medicine
- Oncology
Background:
- The p53 tumor suppressor gene's Arg72Pro polymorphism has been investigated for its association with recurrent pregnancy loss.
- Previous studies yielded inconsistent results regarding this link.
- A meta-analysis was performed to provide a more precise estimation of the association.
Purpose of the Study:
- To evaluate the association between the p53 codon 72 Arg72Pro polymorphism and recurrent pregnancy loss.
- To consolidate evidence from existing case-control studies.
Main Methods:
- A systematic electronic search of PubMed was conducted.
- Included studies were case-control designs with available genotype frequencies for Arg72Pro.
- Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association strength.
Main Results:
- Four case-control studies comprising 523 cases and 378 controls were analyzed.
- Individuals with the homozygous Pro/Pro genotype showed an increased risk of recurrent pregnancy loss (OR = 1.85, 95% CI: 1.078–3.173, p = 0.025).
- Publication bias was assessed and found to be absent through funnel plots and Egger's/Begg's tests.
Conclusions:
- The meta-analysis supports an association between the p53 codon 72 Pro/Pro genotype and an increased risk of recurrent pregnancy loss.
- Further large-scale, prospective international studies are recommended to confirm these findings and establish definitive conclusions.
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