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Related Experiment Video

Updated: May 30, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Oligodendrogliomas in children.

Kimberly M Creach1, Joshua B Rubin, Jeffery R Leonard

  • 1Department of Radiation Oncology and Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

Journal of Neuro-Oncology
|August 16, 2011
PubMed
Summary
This summary is machine-generated.

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Pediatric oligodendrogliomas have excellent survival, but one-third progress. Gross total resection and age over 3 years at diagnosis improve progression-free survival in children with these rare CNS tumors.

Area of Science:

  • Pediatric Oncology
  • Neuro-Oncology
  • Central Nervous System Tumors

Background:

  • Oligodendrogliomas are rare central nervous system (CNS) tumors in children.
  • Identifying prognostic factors is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To identify prognostic factors for progression-free survival (PFS) and overall survival (OS) in pediatric oligodendroglioma patients.

Main Methods:

  • Retrospective analysis of clinical data from 37 pediatric patients.
  • Kaplan-Meier method for survival rates and log-rank test for curve differences.

Main Results:

  • 5-year PFS was 66.4% and OS was 93.4%.
  • Gross total resection (GTR) and age >3 years at diagnosis significantly improved PFS.

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  • Mixed histology was linked to worse OS; neither chemotherapy nor radiation improved outcomes.

    • Conclusions:

    • Pediatric oligodendrogliomas have excellent OS, but disease progression is common.
    • Patients with subtotal resection/biopsy and age <3 years are at higher risk for progression.
    • GTR and older age at diagnosis are key predictors of improved PFS.