Related Experiment Video
Updated: May 30, 2026

Epithelial Cell Infection Analyses with Shigella
Published on: February 9, 2024
Epidemiology and molecular mechanism of integron-mediated antibiotic resistance in Shigella
Xing Ke1, Bing Gu, Shiyang Pan
1Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Abstract:
Integrons are gene capture and expression systems that are characterized by the presence of an integrase gene. This encodes an integrase, a recombined site, and a promoter. They are able to capture gene cassettes from the environment and incorporate them using site-specific recombination. The role of integrons and gene cassettes in the dissemination of multidrug resistance in Gram-negative bacteria is significant. In Shigella species, antimicrobial resistance is often associated with the presence of class 1 and class 2 integrons that contain resistance gene cassettes. Multiple and complex expression regulation mechanisms involving mobile genetic elements in integrons have been developed in the evolution of Shigella strains. Knowledge of the epidemiology and molecular mechanisms of antimicrobial resistance in this important pathogen is essential for the implementation of intervention strategies. This review was conducted to introduce the structures and functions of integrons in Shigella species and mechanisms that control integron-mediated events linked to antibiotic resistance.
Related Concept Videos
Mechanism of Antibiotic Resistance in MRSA
Bacterial Gastroenteritis
Development of Antibiotic Resistance
Microbiota Modulation by Antibiotics
Gene Regulation in Microbial Communities: Quorum Sensing
Clinical Significance of Antibiotic Resistance

