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Updated: May 30, 2026
08:31
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Pathobiology of acute lymphoblastic leukemia
Stefania Paolini1, Anna Gazzola, Elena Sabattini
1Molecular Pathology Laboratory, Hematology Section, Department of Haematology and Oncology L. and A. Sernignoli, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Seminars in Diagnostic Pathology
|August 17, 2011
Summary
This review details the molecular and pathobiological heterogeneity of B- and T-acute lymphoblastic leukemia (ALL). Genetic findings are crucial for prognosis and personalized therapies, transforming ALL treatment paradigms.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Acute lymphoblastic leukemia (ALL) exhibits significant molecular and pathobiological heterogeneity.
- The World Health Organization Classification recognizes distinct ALL entities based on genetic findings.
Purpose of the Study:
- To review the pathobiological features of B- and T-acute lymphoblastic leukemia (ALL).
- To highlight the importance of genetic findings in prognostic stratification and personalized therapeutic approaches for ALL.
Main Methods:
- Review of current literature on B- and T-ALL pathobiology.
- Analysis of the impact of genetic findings on classification and treatment.
Main Results:
- Molecular pathogenesis of ALL is highly heterogeneous.
- Genetic classifications are essential for prognostication.
- Targeted therapies, such as tyrosine kinase inhibitors (TKIs) for Ph+ ALL, have revolutionized treatment.
- Emerging therapies like FLT3 inhibitors, gamma-secretase inhibitors, and monoclonal antibodies show promise.
Conclusions:
- Genetic insights are fundamental for refining ALL classification and improving patient outcomes.
- Personalized therapeutic strategies based on molecular profiles are the future of ALL management.
- Advances in targeted therapies offer new hope for ALL patients, including the elderly.
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