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Related Experiment Video

Updated: May 30, 2026

Enhancing Tumor Content through Tumor Macrodissection

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Published on: February 12, 2022

Molecular pathogenesis of diffuse large B-cell lymphoma.

Christof Schneider¹, Laura Pasqualucci, Riccardo Dalla-Favera

¹Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, and Department of Clinical Pathology and Cell Biology, Columbia University, New York, New York 10032, USA.

Seminars in Diagnostic Pathology

|August 17, 2011

Summary

Diffuse large B-cell lymphoma (DLBCL) pathogenesis is better understood through gene expression profiling and advanced sequencing. This review details the diverse genetic lesions found across different DLBCL subtypes.

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Published on: December 28, 2015

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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Area of Science:

Oncology
Genetics
Molecular Biology

Background:

Significant progress has been made in understanding the pathogenesis of diffuse large B-cell lymphoma (DLBCL).
Gene expression profiling has identified distinct phenotypic subgroups and transcriptional programs within DLBCL.
Emerging technologies have uncovered novel genetic lesions contributing to DLBCL development.

Purpose of the Study:

To review the diversity of genetic lesions identified in various subtypes of diffuse large B-cell lymphoma.
To synthesize current knowledge on the molecular underpinnings of DLBCL heterogeneity.

Main Methods:

Literature review focusing on studies utilizing gene expression profiling.
Analysis of data from next-generation whole genome/exome sequencing.
Examination of findings from genome-wide single nucleotide polymorphism array analysis.

Main Results:

Identification of distinct genetic lesions associated with different DLBCL subtypes.
Elucidation of specific genetic alterations driving disease pathogenesis.
Highlighting the molecular heterogeneity within DLBCL.

Conclusions:

The genetic landscape of diffuse large B-cell lymphoma is complex and heterogeneous.
Understanding these diverse genetic lesions is crucial for targeted therapies and improved patient outcomes.
Continued research into DLBCL pathogenesis will refine classification and treatment strategies.