Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermal Sigmatropic Reactions: Overview01:16

Thermal Sigmatropic Reactions: Overview

Sigmatropic rearrangements are a class of pericyclic reactions in which a σ bond migrates from one part of a π system to another. These are intramolecular rearrangements where the total number of σ and π bonds remain unchanged.
Sigmatropic shifts are classified based on an order term [i, j ], where i and j indicate the number of atoms across which each end of the σ bond migrates. Below are examples of a [3,3] sigmatropic shift in 1,5-hexadiene, referred to as...
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Call For Papers: Molecular Understanding and Formulation Design for Peptide Delivery.

Molecular pharmaceutics·2026
Same author

Analyzing Spatial Variations in Molecular Mobility in Hydrated Amorphous Drug-Polymer Blends Using Fourier Transform Fluorescence Recovery After Photobleaching and Image Segmentation.

The journal of physical chemistry. B·2026
Same author

The expanding role of formulations to enable oral delivery of poorly water-soluble drugs.

Nature reviews. Drug discovery·2026
Same author

Addressing the Release and Permeation Challenges of High-<i>T</i><sub><i>g</i></sub> Drugs in Amorphous Solid Dispersions.

Molecular pharmaceutics·2026
Same author

Investigating the Relationship between In Vitro and In Vivo Performance: The Role of Drug Loading, Release Rate, and Surface Area.

Molecular pharmaceutics·2026
Same author

Role of Dissolution Medium pH in the Release Behavior of Basic Drug-Copovidone Amorphous Solid Dispersions.

Molecular pharmaceutics·2026

Related Experiment Video

Updated: May 30, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Evaluation of amorphous solid dispersion properties using thermal analysis techniques.

Jared A Baird1, Lynne S Taylor

  • 1Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.

Advanced Drug Delivery Reviews
|August 17, 2011
PubMed
Summary
This summary is machine-generated.

Amorphous solid dispersions enhance drug solubility. Thermal analysis methods, like differential scanning calorimetry (DSC), are crucial for characterizing these formulations and ensuring product performance.

More Related Videos

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
09:06

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Published on: July 3, 2020

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing
09:39

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Published on: June 28, 2024

Related Experiment Videos

Last Updated: May 30, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
09:06

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Published on: July 3, 2020

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing
09:39

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Published on: June 28, 2024

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Amorphous solid dispersions (ASDs) are vital for improving the solubility and dissolution of poorly water-soluble drugs.
  • Characterizing ASDs requires advanced analytical methods due to their complex physicochemical nature.

Purpose of the Study:

  • To review the application of thermal analysis techniques for characterizing amorphous solid dispersions.
  • To highlight key parameters influencing ASD performance and the insights gained from thermal measurements.

Main Methods:

  • Differential Scanning Calorimetry (DSC) as a primary technique.
  • Discussion of various established and emerging thermal analytical methods.

Main Results:

  • Thermal techniques provide critical data on glass transition temperature (Tg), molecular mobility, drug-excipient miscibility, and crystallization kinetics.
  • Understanding these parameters is essential for predicting and optimizing ASD performance.

Conclusions:

  • Comprehensive characterization using multi-faceted thermal analysis is key to developing robust amorphous solid dispersion formulations.
  • Evaluating assumptions and limitations of thermal methods ensures reliable characterization.