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Fulminant hepatitis in typhoid fever
1Department of Pediatrics, Faculty of Medicine, P.O. Box 24923, Safat 13110, Kuwait. ehusain@hsc.edu.kw
Journal of Infection and Public Health
|August 17, 2011
Summary
This case report details a rare instance of fulminant hepatitis caused by a co-infection of typhoid fever and hepatitis A in an 11-year-old girl. Fortunately, the patient experienced a complete recovery after treatment.
Area of Science:
- Hepatology
- Infectious Diseases
- Pediatrics
Background:
- Typhoid fever, caused by Salmonella Typhi, is a significant global health concern.
- Hepatitis A is a viral infection affecting the liver, common in certain regions.
- Fulminant hepatitis is a rare but severe complication of liver inflammation.
Observation:
- An 11-year-old girl presented with symptoms suggestive of hepatitis after traveling from India.
- Blood cultures confirmed Salmonella Typhi infection, initiating treatment with ceftriaxone.
- Despite treatment, the patient developed worsening jaundice, elevated liver enzymes, and coagulopathy, indicating severe liver injury.
Findings:
- The patient was diagnosed with a co-infection of typhoid fever and hepatitis A virus.
- The co-infection led to a presentation of fulminant hepatitis.
- Liver function tests and clinical symptoms normalized following appropriate medical management.
Implications:
- This case highlights the potential for severe liver complications when typhoid fever and hepatitis A co-occur.
- Early diagnosis and management of co-infections are crucial for preventing severe outcomes.
- Complete recovery is possible even in cases of fulminant hepatitis due to this dual infection.
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