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Updated: May 30, 2026

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
Published on: February 23, 2021
Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive
Jun-Seob Kim1, Paul Heo, Tae-Jun Yang
1School of Life Science and Biotechnology, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, South Korea.
Abstract:
We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.
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