Initial experience and clinical comparison of two image guidance methods for SBRT treatment: 4DCT versus...

For Stereotactic Body Radiation Therapy (SBRT) treatment of lung and liver, we quantified the differences between two image guidance methods: 4DCT and ExacTrac respiratory-triggered imaging. Five different patients with five liver lesions and one lung lesion for a total of 19 SBRT delivered fractions were studied. For the 4DCT method, a manual registration process was used between the 4DCT image sets from initial simulation and treatment day to determine the required daily image-guided corrections. We also used the ExacTrac respiratory-triggered imaging capability to verify the target positioning, and calculated the differences in image guidance shifts between these two methods. The mean (standard deviation) of the observed differences in image-guided shifts between 4DCT and ExacTrac respiratory-triggered image guidance was left/right (L/R) = 0.4 (2.0) mm, anterior/posterior (A/P) = 1.4 (1.7) mm, superior/inferior (S/I) = 2.2 (2.0) mm, with no difference larger than 5.0 mm in any given direction for any individual case. The largest error occurred in the S/I direction, with a mean of 2.2 mm for the six lesions. This seems reasonable, because respiratory motion and the resulting imaging uncertainties are most pronounced in this S/I direction. Image guidance shifts derived from ExacTrac triggered imaging at two extreme breathing phases (i.e., full exhale vs. full inhale), agreed well (less than 2.0 mm) with each other. In summary, two very promising image guidance methods of 4DCT and ExacTrac respiratory-triggered imaging were presented and the image guidance shifts were comparable for the patients evaluated in this study.