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Updated: May 30, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Published on: October 12, 2017

Oxidized low density lipoproteins--do we know enough about them?

Xueting Jiang¹, Zhaohui Yang, Aluganti Narasimhulu Chandrakala

¹Division of Cardiac Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.

Cardiovascular Drugs and Therapy

|August 17, 2011

Summary

Oxidized low-density lipoprotein (Ox-LDL) plays a role in atherosclerosis, but its complex nature and formation are poorly understood. Clinical trials with antioxidants have yielded disappointing results, prompting a re-evaluation of Ox-LDL

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Published on: October 12, 2017

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

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Published on: November 10, 2017

Area of Science:

Biochemistry
Cardiovascular Biology
Oxidative Stress

Background:

Oxidized low-density lipoprotein (Ox-LDL) is implicated in atherosclerosis.
Lipid peroxidation of polyunsaturated fatty acids (PUFAs) in LDL generates harmful products.
Despite extensive research, the exact nature and in vivo formation of Ox-LDL remain unclear.

Purpose of the Study:

To review the complex nature of Ox-LDL.
To discuss challenges in inhibiting Ox-LDL formation.
To re-evaluate the role of Ox-LDL in atherosclerosis in light of failed antioxidant trials.

Main Methods:

Literature review of studies on Ox-LDL and atherosclerosis.
Analysis of biochemical properties of Ox-LDL components.
Examination of cell surface receptor interactions with Ox-LDL.

Main Results:

Ox-LDL is a heterogeneous mixture with many uncharacterized components.
Aldehydes derived from lipid peroxidation have deleterious biological effects.
Cell surface receptors recognize Ox-LDL, potentially mediating diverse cellular functions.

Conclusions:

The clinical failure of antioxidants suggests a need for alternative strategies.
Understanding the dual nature of Ox-LDL, including potential beneficial effects, is crucial.
Further research is needed to fully elucidate Ox-LDL formation and its in vivo relevance.