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Related Experiment Videos

Ascorbic acid safety: analysis of factors affecting iron absorption.

A Bendich1, M Cohen

  • 1Department of Clinical Nutrition, Hoffmann-LaRoche, Inc., Nutley, NJ 07110.

Toxicology Letters
|April 1, 1990
PubMed
Summary

High doses of ascorbic acid (vitamin C) do not lead to excessive iron absorption. Review of 24 studies shows vitamin C does not significantly impact iron absorption, even at high intakes.

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A STUDY OF THE PENETRATION OF MAMMALIAN CELLS BY DEOXYRIBONUCLEIC ACIDS.

The Journal of biophysical and biochemical cytology·2009

Area of Science:

  • Nutritional Science
  • Gastroenterology
  • Human Physiology

Background:

  • Ascorbic acid (vitamin C) is known to enhance iron absorption.
  • Concerns exist regarding potential excessive iron absorption with high vitamin C intake.
  • The recommended dietary allowance for vitamin C is 60 mg.

Purpose of the Study:

  • To evaluate the potential for excessive iron absorption with ascorbic acid intake above the recommended dietary allowance.
  • To analyze the dose-response relationship between ascorbic acid and iron absorption.
  • To determine the effect of high-dose ascorbic acid on iron absorption parameters.

Main Methods:

  • Systematic literature review of 24 published studies.
  • Analysis of data from 1412 subjects ingesting ascorbic acid within test meals.

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  • Examination of dose-response curves, iron absorption at high iron doses, and plasma transferrin saturation.

    • Main Results:

    • A shallow dose-response curve was observed between ascorbic acid dosage (1-1000 mg) and iron absorption percentage.
    • Ascorbic acid did not significantly affect the absorption of high iron doses (60 mg).
    • Iron absorption showed an inverse relationship with plasma transferrin saturation, and high ascorbic acid doses did not increase 'high' iron absorbers.

    Conclusions:

    • Ingesting ascorbic acid doses above the recommended dietary allowance does not appear to cause excessive iron absorption.
    • The impact of ascorbic acid on iron absorption is limited, particularly at higher iron intakes.
    • Current evidence does not support concerns of detrimental iron overload due to high vitamin C consumption.