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Updated: May 30, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Mechanisms related to neuron injury and death in cerebral hypoxic ischaemia
Min-Fang Guo1, Jie-Zhong Yu, Cun-Gen Ma
1Institute of Brain Science, Medical School, Shanxi Datong University, P.R.China.
Abstract:
Cerebral hypoxic-ischaemic injury is involved in many central nervous system diseases. The mechanisms of neuron injury and death in cerebral hypoxic ischaemia remain unclear. There have been many theories on pathogenesis of neuron injury and death in cerebral hypoxic ischaemia, such as the toxicity of excitatory amino acid, NO, the production of oxygen free radicals, chondriosome injury, complement component, injury of immunological inflammation, matrix metalloproteinase, dopamine, Ca2+ overloading, cell apoptosis and so on. The aim of this review is to describe recent observations regarding the mechanisms of neuron injury and death in cerebral hypoxic ischaemia.
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