A simple and low-cost device for generating hyperpolarized contrast agents using parahydrogen

Area of Science:

• Magnetic Resonance Imaging
• Hyperpolarization Techniques
• Medical Device Development

Background:

• Hyperpolarization significantly enhances Magnetic Resonance Imaging (MRI) signal-to-noise ratio.
• Parahydrogen (H2) is a valuable precursor for inducing hyperpolarization in molecules.
• Efficient transfer of spin order from parahydrogen to target agents is crucial for practical applications.

Purpose of the Study:

• To describe the construction and application of a novel device for hyperpolarizing contrast agents.
• To detail the process of molecular incorporation of spin-order from parahydrogen.
• To demonstrate the utility of the generated hyperpolarized agents in in vivo imaging.

Main Methods:

• Device construction and operational parameters for hyperpolarization.
• Molecular incorporation of spin-order from parahydrogen.
• Order transfer to metastable heteronuclear alignment.
• Optimization of catalyst/solvent choice, solvent heating, and gas entrainment.

Main Results:

• The developed device enables substantial hyperpolarization of select contrast agents.
• Achieved hyperpolarization levels range from a few percent to over 50%.
• Successful demonstration of hyperpolarized agents in in vivo MRI.

Conclusions:

• The described device offers an effective method for producing hyperpolarized contrast agents.
• The achieved hyperpolarization levels are significant for enhancing MRI sensitivity.
• This technique holds promise for advancing in vivo molecular imaging applications.