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Published on: April 1, 2019

[Association of thrombospondin-1 gene N700S polymorphism with coronary artery disease]

Yu-ping Shi1, Hua-lan Gong, Hai-bo Liu

  • 1Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. shiyuping007@hotmail.com

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|August 17, 2011
PubMed

Insights

The thrombospondin-1 (TSP-1) N700S gene variant is present in Chinese populations but at low frequencies. This TSP-1 N700S polymorphism is not associated with coronary artery disease (CAD) or acute myocardial infarction (AMI) risk.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Molecular Biology

Context:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Genetic polymorphisms are increasingly recognized as contributing factors to complex diseases like CAD.
  • Thrombospondin-1 (TSP-1) plays a role in cardiovascular health, making its genetic variants of interest.

Purpose:

  • To investigate the association between the thrombospondin-1 (TSP-1) gene A8831G (N700S) polymorphism and the risk of coronary artery disease (CAD).
  • To determine if the TSP-1 N700S polymorphism is a risk factor for acute myocardial infarction (AMI).

Summary:

  • A case-control study involving 178 CAD patients (55 with AMI) and 158 healthy controls was conducted.
  • The TSP-1 N700S polymorphism was analyzed using polymerase chain reaction and restriction fragment length polymorphism.
  • No significant differences in genotype or allele frequencies were observed between CAD/AMI groups and controls, indicating no association.

Impact:

  • The TSP-1 N700S polymorphism, while present in the Chinese Zhejiang Han population, occurs at a much lower prevalence than in Western populations.
  • This specific TSP-1 N700S variant is unlikely to be a significant genetic risk factor for CAD or AMI in this population.
  • Findings contribute to understanding the genetic landscape of cardiovascular disease risk in diverse ethnic groups.
Abstract

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