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Updated: Feb 3, 2026

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
Published on: August 13, 2021
Inositol safety: clinical evidences
1AGUNCO Obstetrics & Gynecology Center, Rome, Italy. Gianfranco.carlomagno@gmail.com
Myo-inositol, used for Polycystic Ovary Syndrome (PCOS), is generally safe. Mild gastrointestinal issues like nausea and diarrhea were observed only at the highest dose (12 g/day) without increasing severity.
Area of Science:
- Biochemistry
- Pharmacology
- Endocrinology
Background:
- Myo-inositol is a cyclitol with insulin-sensitizing properties.
- It is frequently prescribed for Polycystic Ovary Syndrome (PCOS).
- Limited data exists on its safety profile and potential side effects.
Purpose of the Study:
- To comprehensively review and discuss existing data on the safety of myo-inositol.
- To evaluate safety in both non-clinical and clinical contexts.
Main Methods:
- Literature review of studies investigating myo-inositol safety.
- Analysis of reported side effects across various dosages.
Main Results:
- Myo-inositol is generally well-tolerated.
- The highest dose (12 g/day) was associated with mild gastrointestinal side effects, including nausea, flatus, and diarrhea.
- Increased dosage did not correlate with increased side effect severity.
Conclusions:
- Myo-inositol demonstrates a favorable safety profile.
- Mild gastrointestinal effects at high doses are the primary concern, but are not dose-dependent in severity.
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