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Articles linked to this work by shared authors, journal, and citation graph.

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Same authorSame journal

Retraction Note: A multicenter clinical study with myo-inositol and alpha-lactalbumin in Mexican and Italian PCOS patients.

European review for medical and pharmacological sciences·2026
Same author

Retraction Note: Treatment of lean PCOS teenagers: a follow-up comparison between Myo-Inositol and oral contraceptives.

European review for medical and pharmacological sciences·2026
Same author

Retraction notice to "Contribution of myo-inositol and melatonin to human reproduction". [Eur. J. Obstet. Gynecol. Reprod. Biol. 159 (2011) 267-272].

European journal of obstetrics, gynecology, and reproductive biology·2025
Same author

Retraction notice to "Contribution of myo-inositol to reproduction". [Eur. J. Obstet. Gynecol. Reprod. Biol. 147 (2009) 120-123].

European journal of obstetrics, gynecology, and reproductive biology·2025
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Author Correction: Epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid significantly increase apoptosis and p53 expression in HeLa cells.

European review for medical and pharmacological sciences·2023
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Nebulized myo-inositol increases mucus clearance in patients with Bronchiectasis: a retrospective study.

European review for medical and pharmacological sciences·2023

Related Experiment Video

Updated: Feb 3, 2026

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
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Inositol safety: clinical evidences.

G Carlomagno1, V Unfer

  • 1AGUNCO Obstetrics & Gynecology Center, Rome, Italy. Gianfranco.carlomagno@gmail.com

European Review for Medical and Pharmacological Sciences
|August 18, 2011
PubMed
Summary

Myo-inositol, used for Polycystic Ovary Syndrome (PCOS), is generally safe. Mild gastrointestinal issues like nausea and diarrhea were observed only at the highest dose (12 g/day) without increasing severity.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Endocrinology

Background:

  • Myo-inositol is a cyclitol with insulin-sensitizing properties.
  • It is frequently prescribed for Polycystic Ovary Syndrome (PCOS).
  • Limited data exists on its safety profile and potential side effects.

Purpose of the Study:

  • To comprehensively review and discuss existing data on the safety of myo-inositol.
  • To evaluate safety in both non-clinical and clinical contexts.

Main Methods:

  • Literature review of studies investigating myo-inositol safety.
  • Analysis of reported side effects across various dosages.

Main Results:

  • Myo-inositol is generally well-tolerated.

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  • The highest dose (12 g/day) was associated with mild gastrointestinal side effects, including nausea, flatus, and diarrhea.
  • Increased dosage did not correlate with increased side effect severity.

    • Conclusions:

    • Myo-inositol demonstrates a favorable safety profile.
    • Mild gastrointestinal effects at high doses are the primary concern, but are not dose-dependent in severity.