Ketoprofen 2.5% gel: a clinical overview

Area of Science:

• Pharmacology
• Rheumatology
• Dermatology

Background:

• Ketoprofen (KP), a nonsteroidal anti-inflammatory drug (NSAID), is used for musculoskeletal pain and inflammation.
• Oral NSAIDs, including KP, are linked to systemic adverse events, particularly gastrointestinal issues.
• Topical application offers localized efficacy with reduced systemic exposure.

Purpose of the Study:

• To provide an overview of topical ketoprofen (tKP) 2.5% gel for musculoskeletal conditions.
• To evaluate the efficacy and safety of tKP 2.5% gel compared to oral administration.
• To consolidate data from clinical trials and real-world practice.

Main Methods:

• Review of pharmacokinetic data comparing topical and oral KP.
• Analysis of clinical studies evaluating tKP 2.5% gel in musculoskeletal conditions.
• Inclusion of data from real-life clinical practice.

Main Results:

• Topical KP 2.5% gel demonstrates local effectiveness for pain and inflammation.
• Serum levels of tKP are less than 1% of oral doses, significantly reducing systemic adverse events.
• Clinical studies show benefits in various musculoskeletal conditions with twice-daily application.

Conclusions:

• Topical ketoprofen 2.5% gel is an effective treatment option for musculoskeletal pain and inflammation.
• It offers a favorable safety profile by minimizing systemic adverse events common to oral NSAIDs.
• Caution is advised regarding photosensitization, with avoidance of sun exposure during and after treatment.