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Selective lymphadenectomy for penile cancer
S Bucher1, M Guerra, D Ribuffo
1Division of Plastic Surgery, Istituto San Gallicano IRCCS, Rome, Italy.
European Review for Medical and Pharmacological Sciences
|August 18, 2011
Summary
Selective lymphadenectomy (SLND) for penile cancer improves survival rates in node-negative patients. This procedure offers better outcomes than surveillance alone, with further improvements possible through better metastasis markers.
Area of Science:
- Oncology
- Surgical Oncology
- Penile Cancer Research
Background:
- Debate on lymph node treatment in penile cancer patients over the last 15 years.
- Surgeons advocate either therapeutic lymphadenectomy or selective lymphadenectomy (SLND).
Purpose of the Study:
- To evaluate the outcomes of clinically node-negative penile cancer patients treated with SLND.
- To assess the efficacy of SLND in managing lymph node status in penile cancer.
Main Methods:
- Retrospective evaluation of 35 node-negative penile cancer patients treated with SLND since March 2000.
- Sentinel node detection was performed in 42 groins.
- Minimum follow-up of five years.
Main Results:
- A sentinel node was detected in 34 out of 35 patients.
- Metastases were identified in 5 out of 35 patients.
- 2 out of the remaining 30 patients developed metastases in the operated inguinal region (6.6% incidence).
Conclusions:
- SLND for penile cancer significantly improves survival and disease-free rates compared to surveillance alone (91% vs 79% at 3 years).
- Further research into specific markers for squamous cell carcinoma (SCC) lymph node metastases is needed to reduce the false-negative rate.