[Trigger mechanism of neuroprotective effect of ischemic preconditioning]

Analysis of literature data indicates that adenosine, glutamate, NO, reactive oxygen species, erythropoietin, interleukin-1 are triggers of delayed preconditioning of brain. The issue of involvement of bradykinin, opioids, TNF-alpha in preconditioning remains unclear, although possibility of these compounds to induce a state of increased tolerance to ischemia does not induce a doubt. It was established that adenosine receptor agonists, bradykinin, opioids, NO* donors can mimic a phenomenon of early preconditioning.