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[Methodology and assessment of testing bronchial reactivity]
1Zentralinstitut für Arbeitsmedizin der DDR, Klinik und Poliklinik für Berufskrankheiten.
Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1990
Summary
This study discusses the acetylcholine challenge test for diagnosing bronchial hyperreactivity, a standard in GDR since 1974. It also explores a histamine threshold method for specialized applications, highlighting the significance of bronchial hyperreactivity.
Area of Science:
- Pulmonary Medicine
- Clinical Diagnostics
- Pharmacology
Background:
- Non-specific bronchial challenges are diagnostically relevant.
- Since 1974, the German Democratic Republic (GDR) has utilized an acetylcholine challenge test as a standard screening method.
- Non-specific bronchial hyperreactivity (NBH) has significant diagnostic, prognostic, and expertizing implications.
Purpose of the Study:
- To discuss the principles and experiences of the screening-type acetylcholine test for diagnosing NBH.
- To present a modified histamine threshold method for specialized applications like longitudinal studies and clinical pharmacology.
- To emphasize the diagnostic, prognostic, and expertizing relevance of NBH.
Main Methods:
- Review of principles and experiences with the screening-type acetylcholine test.
- Derivation and modification of a histamine threshold method from existing literature.
- Focus on diagnostic, prognostic, and expertizing aspects of NBH assessment.
Main Results:
- The acetylcholine test has been a standard screening tool in the GDR since 1974.
- A histamine threshold method has been developed for specialized research and clinical needs.
- NBH is crucial for diagnosis, prognosis, and expert evaluations.
Conclusions:
- The acetylcholine challenge test is a valuable tool for screening NBH.
- The histamine threshold method offers a flexible approach for specific NBH investigations.
- Understanding and assessing NBH is critical across various clinical and research settings.