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Updated: May 30, 2026

Measurement of Total Calcium in Neurons by Electron Probe X-ray Microanalysis
Published on: November 20, 2013
Mitochondrial calcium handling during ischemia-induced cell death in neurons
Yves Gouriou1, Nicolas Demaurex, Philippe Bijlenga
1Department of Cell Physiology and Metabolism, University of Geneva, rue Michel-Servet 1, Genève, Switzerland.
Abstract:
Mitochondria sense and shape cytosolic Ca(2+) signals by taking up and subsequently releasing Ca(2+) ions during physiological and pathological Ca(2+) elevations. Sustained elevations in the mitochondrial matrix Ca(2+) concentration are increasingly recognized as a defining feature of the intracellular cascade of lethal events that occur in neurons during cerebral ischemia. Here, we review the recently identified transport proteins that mediate the fluxes of Ca(2+) across mitochondria and discuss the implication of the permeability transition pore in decoding the abnormally sustained mitochondrial Ca(2+) elevations that occur during cerebral ischemia.
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