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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Prognostic value of right ventricular diastolic function indices in hypertrophic cardiomyopathy

Efstathios D Pagourelias1, Georgios K Efthimiadis, Despoina G Parcharidou

  • 1Cardiomyopathies Laboratory, 1st Cardiology Department, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. statpag@yahoo.gr

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
|August 18, 2011
PubMed

Insights

Right ventricular diastolic dysfunction in hypertrophic cardiomyopathy (HCM) patients predicts worse outcomes. Increased right ventricular E/E(r) ratio and shortened tricuspid E wave deceleration time are significant indicators of heart failure mortality and sudden cardiac death risk.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Diseases

Background:

  • Left ventricular diastolic dysfunction is a known prognostic factor in hypertrophic cardiomyopathy (HCM).
  • The prognostic impact of right ventricular (RV) diastolic dysfunction in HCM remains less understood.
  • Assessing RV diastolic function may offer new insights into HCM prognosis.

Purpose of the Study:

  • To evaluate the prognostic significance of transthoracic echocardiographic indices of RV diastolic function in HCM patients.
  • To determine if RV diastolic filling pressures impact patient outcomes.
  • To identify specific echocardiographic markers of RV diastolic dysfunction with predictive value.

Main Methods:

  • Retrospective analysis of 386 HCM patients followed for a median of 67 months.
  • Transthoracic echocardiography was used to assess RV diastolic function using tricuspid inflow and tissue Doppler imaging.
  • Primary endpoints included mortality due to heart failure (HF) and total cardiovascular (TC) mortality.

Main Results:

  • An increased RV E/E(r) ratio was associated with a 1.6-fold higher risk of HF mortality (P=0.03).
  • Shortened tricuspid E wave deceleration time (DTE) was linked to a 1.1-fold higher risk of sudden cardiac death (P=0.03).
  • Optimal cut-off values were identified: RV E/E(r) ratio of 6.88 for HF mortality and DTE < 239 ms for TC mortality.

Conclusions:

  • Right ventricular restrictive physiology has significant predictive value in HCM prognosis.
  • RV diastolic dysfunction indices are important markers for risk stratification in HCM patients.
  • These findings may aid in refining management strategies for HCM.
Abstract

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