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Drug surveillance programme in psychiatry - adverse durg reactions

L P Shah1, K S Ayyar, B R Agarawal

  • 1Prof. of Psychiatry, Department of Psychiatry & Department of Pharmacology & Clinical Pharmacology Unit, Seth G. S. Medical College & K.E.M. Hospital, Parel, Bombay 400 012.

Indian Journal of Psychiatry
|August 18, 2011
PubMed

Insights

Adverse drug reactions were reported by 32.8% of patients, with most being mild to moderate. These side effects were manageable, allowing treatment continuation without major changes or unusual reactions.

Area of Science:

  • Clinical Pharmacology
  • Patient Safety
  • Drug Monitoring

Background:

  • Adverse drug reactions (ADRs) are a significant concern in healthcare settings.
  • Monitoring ADRs is crucial for ensuring patient safety and optimizing pharmacotherapy.

Purpose of the Study:

  • To assess the incidence, characteristics, and management of adverse drug reactions in hospitalized patients.
  • To determine the impact of ADRs on treatment continuation and patient outcomes.

Main Methods:

  • Clinically monitored surveillance of 186 indoor patients over an average two-week hospital stay.
  • Data collection on reported side-effects, intensity, management strategies, and treatment changes.

Main Results:

  • 32.8% of patients experienced side-effects, with 79.3% being mild to moderate.
  • Side-effects were manageable, allowing continued medication in most cases.
  • No association found between side-effects and patient demographics or clinical factors.
  • Treatment changes were infrequent (7.3%), and no unusual or toxic reactions were observed.

Conclusions:

  • Adverse drug reactions in this patient sample were generally mild and manageable.
  • Current pharmacotherapy profiles align with observed side-effects.
  • Effective management strategies can prevent significant treatment disruption from ADRs.

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